Creatine Kinase Isoenzyme MB (CKMB) Controversy: Perimortal Tissue Acidosis May Explain the Absence of CKMB in Myocardium at Autopsy
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منابع مشابه
ACS Acute coronary syndrome MI Myocardial infarction CK Creatine kinase CKMB creatine kinase MB-fraction
Özet– Alerjik semptomların miyokart iskemisi semptomlarına eşlik etmesi Kounis sendromu olarak tanımlanır. Etofenamat sık olarak kullanılan güvenli ve etkin bir steroid olmayan antienflamatuvar ilaçtır. Bu yazıda Kounis sendromlu 71 yaşında erkek hasta sunuldu. İntramüsküler 1 gram etofenamat enjeksiyonu sonrası eritamatöz döküntüler, kaşıntı, bulantı ve kusma, baş dönmesi, terleme ve göğüs ağr...
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Serial measurements of the MB isoenzyme of creatine kinase, total creatine kinase, aspartate mainotransferase, and urea stable lactate dehydrogenase have been made in the serum of a series of 139 patients admitted with a diagnosis of suspected myocardial infarction. Serum MB isoenzyme measurements have also been made on postoperative surgical patients and patients with medical disorders known t...
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Chromatography on DEAE-Sephadex A-50 was applied to study the quantitative distribution of creatine kinase isoenzymes in extracts of human tissue obtained during surgery. The results are compared with those determined by an immunological method [Clin. Chim. Acta 58, 223 (1975)]. Conflicting results for some organs as reported by the two methods are probably attributable to postmortem autolysis.
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Several methods are available for specifically identifying and assessing the activity of MB isoenzyme of creatine kinase in serum. We compared two electrophoretic techniques with three column-chromatographic ones for efficacy in the diagnosis of myocardial infarction. No technique was considered absolute, but we found surprisingly large errors of diagnosis in the column-chromatographic techniqu...
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A 20-year-old man was found to have high plasma creatine kinase (EC 2.7.3.2) activity in association with a rhabdomyosarcoma of the prostate. There was a very high proportion of the MB isoenzyme. Clinical findings and changes in creatine kinase activity with time showed that this increase was not ascribable to myocardial disease. We believe that the high proportion of CK-MB, confirmed by a comb...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2001
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/47.9.1733